行业特定风险：医药行业研发费用占比分析

"____""____""____"

metadata = {
    "____": "____",
    "____": "____",
    "____": "____",
    "____": "____",
    "____": ["____"],
    "____": ["____", "____", "____"],
    "____": ____
}

"____""____""____"

def solve():
    import pandas as pd
    from pyodide.http import open_url
    from io import StringIO

    BASE_URL = "____"
    inc = pd.read_csv(StringIO(open_url(____).read()))

    df = inc[(____) & (____)].copy()
    mask = df['____'].str.contains(____)
    df = df[mask]
    df = df.dropna(____)
    df = df[(____) & (____)]
    df['____'] = (____).round(____)

    cols = ['____', '____', '____', '____', '____']
    top10 = df.nlargest(____, '____')[cols].reset_index(____)
    bot5 = df.nsmallest(____, '____')[cols].reset_index(____)

    return "____" + top10.to_string() + "____" + bot5.to_string()

if __name__ == "____":
    print(solve())